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Curcumin and Immune System

Curcumin and Immune System

Several Immkne reported that curcumin downregulates Imnune proliferation Systek T cells Balanced weight loss by concanavalin A Con Curcumin and Immune SystemIImmune PHAand Curcuminn PMA Töpfer K, Kempe S, Müller N, Anv M, Bachmann M, Cartellieri M, et al. Despite this, sometimes cancer emerges as violence due to the internal riot of some cells, called tumor cells. Terry CM, Clikeman JA, Hoidal JR, Callahan KS: Effect of tumor necrosis factor-α and interleukin-1α on heme oxygenase-1 expression in human endothelial cells. J Biochem Mol Biol 35 3 —, PubMed CAS Google Scholar Jian YT, Mai GF, Wang JD, Zhang YL, Luo RC, Fang YX: Preventive and therapeutic effects of NF-κB inhibitor curcumin in rats colitis induced by trinitrobenzene sulfonic acid. You can also find turmeric as an ingredient in immunity support tablets, like Nuun Immunity. In addition, depletion of toll-like receptor-9 TLR9 and reduced IFNα secretion by pDCs have been recorded in the TME. Curcumin and Immune System

Curcumin and Immune System -

However, due to the numerous immunosuppressive cytokines in the tumor immunosuppressive microenvironment, the efficacy of adoptive T-cell therapy is often transient and prone to failure In the E.

These results showed that combination therapy had greater efficacy compared with adaptive T-cell therapy alone. Different doses of curcumin were administered to mice bearing tumors derived from the 3LL breast cancer cell line and a low dose of curcumin led to delayed tumor growth and prolonged survival of the mice.

Moreover, the combination of an intravenously administered polyethylene glycol curcumin coupler, rather than an oral formulation, and a tyrosinase-related peptide vaccine for the treatment of melanoma significantly increased the CTL response and IFN-γ expression levels compared with the vaccine alone, while the combination therapy also decreased the levels of tumor immunosuppressive cells, such as marrow-derived suppressor cells and Treg cells During the gradual shaping of the tumor immunosuppressive microenvironment, various cytokines are considered to serve a crucial role in regulating the composition and proportions of the cancer-promoting immune cell component and the cancer-suppressing immune cell component Curcumin, as a tumor inhibitor, not only facilitates the secretion of cancer-promoting cytokines, but also inhibits the secretion of cancer-suppressing cytokines, thereby remodeling the tumor immunosuppressive microenvironment IL-2 plays a dual role, stimulating and inhibiting the tumor immune response.

Since high-affinity IL-2 receptor IL-2R is highly expressed on the surface of Treg cells, IL-2 is a tumor promoter activating Treg cells Curcumin directly inhibits the interaction between IL-2 and IL-2Rα CD25 , thus inhibiting the activation of Treg cells Curcumin also downregulates the levels of TGF-β and IL in Treg cells, reduces their ability to stimulated Treg cells and decreases the Treg cell infiltration in tumors An increased expression level of IL-6 in triple-negative breast cancer is considered to mediate the tumor immunosuppressive microenvironment, leading to tumor vaccine therapy failure Curcumin is a specific inhibitor of IL-6, and the combination of curcumin and breast cancer vaccine Listeriaat-Mage-b resulted in decreased IL-6 expression levels and increased IL and IFN-γ levels, resulting in greater anti-tumor efficacy compared with using vaccine alone However, Bill et al showed different results.

Although previous reports showed that curcumin promoted tumor apoptosis 36 — 38 , curcumin-pretreated human A melanoma cells led to STAT1 phosphorylation inhibition and decreased downstream IFN-γ and IFN-α expression levels. In addition, co-culture of NK cells and these curcumin-pretreated melanoma cells also reduced ILinduced IFN-γ expression, which indicated curcumin may also inhibit the expression of cancer-suppressing cytokines.

Curcumin not only influences adaptive immunity through regulating T cell proliferation and apoptosis, but it also influences NK cell-mediated innate immunity Curcumin may inhibit the cytotoxicity of exosomes to circulating immune cells by disrupting the ubiquitin protease system and increasing the ubiquitinated exosomal proteins that interfere the function of normal exosomal proteins In addition, the effect of curcumin on promoting cytotoxic ability of NK cells is also associated with the activation of STAT4 and STAT5 in NK cells and the suppression of pERK and PI3K expression in curcumin-induced breast cancer cells In a study of pancreatic cancer, curcuminoids enhanced the ability of NK cells to secrete IFN-γ and promoted the killing effect of NK cells in pancreatic cancer cell lines The former exhibit tumor-suppressing functions while the latter show tumor-promoting ability.

M1 TAMs show high expression levels of IL and low expression levels of IL, whereas M2 TAMs exhibit the opposite expression Subsequently, M1 TAMs induced STAT1 and NF-κB p65 expression, subsequently increasing the expression levels of IL and thereby activating NK cells and CTLs, resulting in cytotoxicity The same mechanism of action was also demonstrated in malignant glioma , Since , when Kuttan et al first conducted a clinical trial of curcumin for the treatment of external cancerous cancer, several clinical trials of curcumin alone or in combination with other cancer therapeutics have been widely carried out.

At present, randomized, controlled, double-blind clinical trials of curcumin are mainly concentrated on pancreatic cancer , colorectal cancer , prostate cancer and breast cancer , whereas clinical trials for other tumors are currently underway.

As early as , a clinical trial of 25 patients with advanced pancreatic cancer showed that despite the low bioavailability rate of the curcumin oral formulation, the formulation can be tolerated and had good clinical biological activity in several patients In addition, administrating curcumin significantly downregulated the expression levels of NF-κB, cyclooxygenase and phosphorylated STAT3 in peripheral blood mononuclear cells To address the low bioavailability of curcumin, a recent clinical trial investigated the combination of phospholipid-coated curcumin using nanotechnology and gemcitabine Although the patient quality of life was not significantly improved during treatment, the patient drug response rate reached Therefore, curcumin combined with gemcitabine is may be a safe and effective therapy for wider application for pancreatic cancer treatment; however, before the combination of curcumin and gemcitabine therapy can become routine therapy for pancreatic cancer large multicentric randomized controlled trials need to be conducted.

The recent ongoing and completed clinical trials of curcumin in diverse tumors are summarized in Table I by referring to clinicaltrials. Curcumin, a traditional food ingredient, has been identified to serve versatile roles in the prevention and treatment of several diseases — Curcumin has also been identified to inhibit a variety of biological functions of tumors, including growth, proliferation, invasion, metastasis, apoptosis, angiogenesis and drug resistance of tumor cells In the present review, highlighted the role of the tumor immunosuppressive microenvironment in tumor progression and the functions of curcumin in modulating and remodeling the tumor immunosuppressive microenvironment have been highlighted.

Therefore, given the multiple functions and good biosafety of curcumin in inhibiting tumor progression, as a tumor-preventing food and tumor-assisted therapeutic drug, curcumin has potential in tumor treatment potential in combination with multimodal anticancer therapies.

However, curcumin has several limitations in clinical practice such as its low bioavailability, drug dose-effect disproportion and poor water solubility To address these problems, an increasing numbers of studies are focusing on how to enhance the tolerance of curcumin, improve the targeting of curcumin delivery, overcome low bioavailability and obtain better therapeutic effects , A variety of nano-curcumin formulations have been introduced, which have improved the anti-cancer effects of curcumin , It is considered that curcumin will serve a more important role in the prevention and treatment of cancer in the future.

The present study was supported by The China Academy of Medical Sciences Innovation Fund for Medical Sciences grant no. In this review, the concept and design was conducted by YW and JG.

YW and JL drafted the manuscript. Tables and diagrams were generated by JL and BJ. Critical revision of the manuscript for important intellectual content was conducted by YW, JL and BJ.

JG provided the funding support. All authors read and approved the final manuscript. Siegel RL, Miller KD and Jemal A: Cancer statistics, CA Cancer J Clin. Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, Tartari F, Santoni M, Pistelli M and Berardi R: Healthcare cost of HER2-positive and negative breast tumors in the United States — Cancer Treat Rev.

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Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. Sato Y, Yoshino H, Tsuruga E and Kashiwakura I: Fas ligand enhances apoptosis of human lung cancer cells cotreated with RIG-I-like receptor agonist and radiation.

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J Cell Physiol. Harini L, Srivastava S, Gnanakumar GP, Karthikeyan B, Ross C, Krishnakumar V, Kannan VR, Sundar K and Kathiresan T: An ingenious non-spherical mesoporous silica nanoparticle cargo with curcumin induces mitochondria-mediated apoptosis in breast cancer MCF-7 cells.

Moustakas A and Heldin CH: Non-Smad TGF-beta signals. J Cell Sci. Oncol Lett. Chen YY, Lin YJ, Huang WT, Hung CC, Lin HY, Tu YC, Liu DM, Lan SJ and Sheu MJ: Demethoxycurcumin-loaded chitosan nanoparticle downregulates DNA repair pathway to improve cisplatin-induced apoptosis in non-small cell lung cancer.

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Phytother Res. Cao MT, Liu HF, Liu ZG, Xiao P, Chen JJ, Tan Y, Jiang XX, Jiang ZC, Qiu Y, Huang HJ, et al: Curcumin downregulates the expression of Snail via suppressing Smad2 pathway to inhibit TGF-β1-induced epithelial-mesenchymal transitions in hepatoma cells.

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Dunn GP, Koebel CM and Schreiber RD: Interferons, immunity and cancer immunoediting. Nat Rev Immunol. However, turmeric has been shown to boost the immune system. You would have to consume a large amount of turmeric to get the same benefits as a supplement. You can whip up this warm drink with just a few ingredients: milk typically coconut, almond, or cashew milk , turmeric, black pepper, cinnamon, and maple syrup.

If you prefer a supplement, you can find them in several forms:. You can also find turmeric as an ingredient in immunity support tablets, like Nuun Immunity.

The typical recommended dosage for turmeric ranges from mg to 2,mg per day. However, make sure to talk to your doctor before starting a new supplement.

What Does Turmeric Taste Like? While the health benefits of turmeric may be enticing, you may still have questions about the taste — especially given its vibrant, yellow-orange color. According to the food experts at Bon Appetit , turmeric tastes earthy and bitter, with a peppery spice.

What Are the Side Effects of Turmeric? Turmeric is generally recognized as a safe addition to your diet. While very few people have experienced side effects from consuming turmeric, some have complained of nausea and diarrhea — but only when taking high doses.

Ultimately, incorporating turmeric into your diet can help you maintain your active lifestyle. With less muscle soreness, a better immune system, and less inflammation, you can keep running, cycling, and exercising with confidence. Looking for an easy way to add more turmeric to your daily routine?

Try Nuun Immunity. Blueberry Tangerine. Nuun Sport Nuun Immunity Nuun Vitamins Nuun Endurance Mixed Packs Accessories Hydrated Rejuvenated Daily Support Peak Performance. Blog About Us Our Team Reasons to Believe In the Press 5 Signs You're Dehydrated The Health Benefits of Turmeric Drinking Water Isn't Enough What Can Tart Cherry Do For You?

The Health Benefits of Turmeric: How It Can Boost Your Active Lifestyle. Health Immunity. If you prefer a supplement, you can find them in several forms: Capsules or tablets Gummies Liquids You can also find turmeric as an ingredient in immunity support tablets, like Nuun Immunity.

Antioxidants can fight free radicals and may reduce or even help prevent some of the damage they cause. In addition, curcumin lowers the levels of two enzymes in the body that cause inflammation. It also stops platelets from clumping together to form blood clots.

Curcumin stimulates the gallbladder to produce bile, which some people think may help improve digestion. The German Commission E, which determines which herbs can be safely prescribed in Germany, has approved turmeric for digestive problems.

And one double-blind, placebo-controlled study found that turmeric reduced symptoms of bloating and gas in people suffering from indigestion. Turmeric may help people with ulcerative colitis stay in remission. Ulcerative colitis is a chronic disease of the digestive tract where symptoms tend to come and go.

In one double-blind, placebo-controlled study, people whose ulcerative colitis was in remission took either curcumin or placebo, along with conventional medical treatment, for 6 months.

Those who took curcumin had a significantly lower relapse rate than those who took placebo. Turmeric does not seem to help treat stomach ulcers. In fact, there is some evidence that it may increase stomach acid, making existing ulcers worse. See "Precautions" section. Because of turmeric's ability to reduce inflammation, researchers have wondered if it may help relieve osteoarthritis pain.

One study found that people using an Ayurvedic formula of herbs and minerals with turmeric, winter cherry Withinia somnifera , boswellia Boswellia serrata , and zinc had less pain and disability.

But it's impossible to know whether turmeric, one of the other supplements, or all of them together, was responsible for the effects. Early studies suggested that turmeric may help prevent atherosclerosis, the buildup of plaque that can block arteries and lead to heart attack or stroke.

In animal studies, an extract of turmeric lowered cholesterol levels and kept LDL bad cholesterol from building up in blood vessels. Because it stops platelets from clumping together, turmeric may also prevent blood clots from building up along the walls of arteries.

But a double-blind, placebo-controlled study found that taking curcumin, the active ingredient in turmeric, at a dose of up to 4 g per day did not improve cholesterol levels.

There has been a great deal of research on turmeric's anti-cancer properties, but results are still preliminary. Evidence from test tube and animal studies suggests that curcumin may help prevent or treat several types of cancers, including prostate, breast, skin, and colon cancer.

Tumeric's preventive effects may relate to its antioxidant properties, which protect cells from damage. More research is needed. Cancer should be treated with conventional medications. Don't use alternative therapies alone to treat cancer.

If you choose to use complementary therapies along with your cancer treatment, make sure you tell all your doctors. Test tube and animal studies suggest turmeric may kill bacteria and viruses, but researchers don't know whether it would work in people.

A preliminary study suggests curcumin may help treat uveitis, an inflammation of the eye's iris. Preliminary research suggests that curcumin may be as effective as corticosteroids, the type of medication usually prescribed. Tumeric's powerful antioxidant, anti-inflammatory, and circulatory effects may help prevent and treat neurodegenerative diseases, including Alzheimer disease, Parkinson's disease, multiple sclerosis, and other conditions.

A relative of ginger, turmeric is a perennial plant that grows 5 to 6 feet high in the tropical regions of Southern Asia, with trumpet-shaped, dull yellow flowers. Its roots are bulbs that also produce rhizomes, which then produce stems and roots for new plants.

Turmeric is fragrant and has a bitter, somewhat sharp taste. Although it grows in many tropical locations, the majority of turmeric is grown in India, where it is used as a main ingredient in curry. The roots, or rhizomes and bulbs, are used in medicine and food.

They are generally boiled and then dried, turning into the familiar yellow powder. Curcumin, the active ingredient, has antioxidant properties. Other substances in this herb have antioxidant properties as well. Bromelain increases the absorption and anti-inflammatory effects of curcumin, so it is often combined with turmeric products.

Pediatric Turmeric supplements haven't been studied in children, so there is no recommended dose. The use of herbs is a time-honored approach to strengthening the body and treating disease.

However, herbs can trigger side effects and may interact with other herbs, supplements, or medications. For these reasons, you should take herbs with care, under the supervision of a health care provider. Turmeric in food is considered safe. However, taking large amounts of turmeric and curcumin in supplement form for long periods of time may cause stomach upset and, in extreme cases, ulcers.

People who have gallstones or obstruction of the bile passages should talk to their doctor before taking turmeric. If you have diabetes, talk to your doctor before taking turmeric supplements. Turmeric may lower blood sugar levels. When combined with medications for diabetes, turmeric could cause hypoglycemia low blood sugar.

Although it is safe to eat foods with turmeric, pregnant and breastfeeding women should not take turmeric supplements. Because turmeric may act like a blood thinner, you should stop taking it at least 2 weeks before surgery. Tell your doctor and surgeon that you have been taking turmeric.

If you are being treated with any of the following medications, you should not use turmeric or curcumin in medicinal forms without first talking to your health care provider.

Turmeric may strengthen the effects of these drugs, raising the risk of bleeding. Blood thinners include warfarin Coumadin , clopidogrel Plavix , and aspirin, among others. Turmeric may interfere with the action of these drugs, increasing the production of stomach acid:.

Turmeric may strengthen the effects of these drugs, increasing the risk of hypoglycemia low blood sugar. Aggarwal BB, Yuan W, Li S, Gupta SC. Curcumin-free tumeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of tumeric.

Mol Nutr Food Res. Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. Asai A, Miyazawa T.

Systej, the main bioactive component found Curcumin and Immune System turmeric, has garnered significant attention in recent years due to its Forskolin and stress management health benefits, particularly for Digestive health benefits immune ajd. Curcumin and Immune System plays a crucial role in the immune response, helping the body defend against infections Inmune injuries. However, SSystem inflammation can weaken the immune system and Imumne to various diseases. Curcumin is known for its potent anti-inflammatory propertieswhich can help modulate the immune system and reduce excessive inflammation [1]. Curcumin exerts its anti-inflammatory effects by inhibiting the production of pro-inflammatory molecules, such as tumour necrosis factor-alpha TNF-α and interleukins ILand by suppressing the activation of nuclear factor kappa B NF-κBa critical regulator of inflammation [2] [3]. By inhibiting these pro-inflammatory pathways, curcumin can help support a balanced immune response. Oxidative stress, caused by an imbalance between the production of reactive oxygen species ROS and the body's antioxidant defences, can damage cells and weaken the immune system. Immund, everyone is Acai berry immune boosters to Body fat analysis their Systen system. Instead, it Curcumin and Immune System a while for dietary and lifestyle changes to kick-in. Excessive immune responses following infection can cause a Sports nutrition experts of health problems, and Cuecumin some cases, even death. Sluggish immune responses are not optimal either, as those who are immunosuppressed may not be able to produce enough inflammation or effectively coordinate the biochemical reactions needed to clear an infection. Fighting a virus takes a fine-tuned immune system—one that can launch a strong attack at the first sign of infection, but also knows when to scale down the attack once the virus subsides.

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