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Astaxanthin and metabolic function

Astaxanthin and metabolic function

Kang, Metablic. Induction of Asatxanthin during Astaxanthin and metabolic function and association of GLUT4 with caveolin-rich vesicles. Biotechnol Bioproc E 22 3 — A Bar graph showing differentially regulated proteins among all the groups. Franckhauser, S.


5 Supplements To Enhance Our Mitochondrial Health - Dr David Sinclair Interview Clips Because oxidative stress promotes insulin resistance in obesity and Fumction 2 diabetes, it is fhnction to find effective antioxidant for the purpose of decreasing this threat. Peak performance gut health program this study, we Astaxanthinn the effect of astaxanthin, ,etabolic carotenoid antioxidant, Astaxanthin and metabolic function insulin signaling and investigated whether astaxanthin improves cytokine- and free fatty acid-induced insulin resistance in vitro. We examined the effect of astaxanthin on insulin-stimulated glucose transporter 4 GLUT4 translocation, glucose uptake, and insulin signaling in cultured rat L6 muscle cells using plasma membrane lawn assay, 2-deoxyglucose uptake, and Western blot analysis. Next, we examined the effect of astaxanthin on TNFα- and palmitate-induced insulin resistance. The amount of reactive oxygen species generated by TNFα or palmitate with or without astaxanthin was evaluated by dichlorofluorescein staining.

Astaxanthin and metabolic function -

Astaxanthin, a xanthophyll carotenoid, accelerates lipid utilization during aerobic exercise, although the underlying mechanism is unclear.

The present study investigated the effect of astaxanthin intake on lipid metabolism associated with peroxisome proliferator-activated receptor-γ coactivator-1α PGC-1α in mice. Mice were divided into 4 groups: sedentary, sedentary and astaxanthin-treated, exercised, and exercised and astaxanthin-treated.

Immediately after running, intermuscular pH was measured in hind limb muscles, and blood was collected for measurements. Proteins were extracted from the muscle samples and PGC-1α and its downstream proteins were measured by western blotting. Levels of plasma fatty acids were significantly decreased after exercise in the astaxanthin-fed mice compared with those fed a normal diet.

Intermuscular pH was significantly decreased by exercise, and this decrease was inhibited by intake of astaxanthin. Levels of PGC-1α and its downstream proteins were significantly elevated in astaxanthin-fed mice compared with mice fed a normal diet. Astaxanthin intake resulted in a PGC-1α elevation in skeletal muscle, which can lead to acceleration of lipid utilization through activation of mitochondrial aerobic metabolism.

Already have an account? Sign in here. Disclosure Summary: The authors declare that this study was partially supported by an unconditional grant from AstaReal Co, Ltd Toyama, Japan , which produces astaxanthin.

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Nakayama and K. Hara for technical assistance and animal care. Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, , Japan. Department of Pathology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, , Japan.

You can also search for this author in PubMed Google Scholar. and N. performed experiments. and Y. contributed to human data analysis. contributed to discussion and edited the manuscript. performed experiments and wrote the manuscript. is the guarantor of this work and, as such, had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

This work is licensed under a Creative Commons Attribution 4. Reprints and permissions. Sci Rep 5 , Download citation. Received : 31 July Accepted : 27 October Published : 25 November Anyone you share the following link with will be able to read this content:.

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Skip to main content Thank you for visiting nature. nature scientific reports articles article. Download PDF. Subjects Metabolic syndrome Non-alcoholic steatohepatitis. Abstract Hepatic insulin resistance and nonalcoholic steatohepatitis NASH could be caused by excessive hepatic lipid accumulation and peroxidation.

Figure 1. Full size image. Table 1 Effects of astaxanthin AX and vitamin E VE on metabolic parameters after 12 weeks of treatment. Full size table. Figure 2. Astaxanthin prevented the development of hepatic steatosis in NASH mice. Figure 3. Astaxanthin ameliorated diet-induced glucose intolerance and hepatic insulin resistance.

Figure 4. Astaxanthin attenuated hepatic inflammation and fibrosis in NASH mice.

Thank you for visiting nature. You are using a Astaxanthih version with limited Fuel Efficiency Optimization for Snd. To obtain the Asraxanthin experience, Astaxanthin and metabolic function recommend you use a metaabolic up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Hepatic insulin resistance and nonalcoholic steatohepatitis NASH could be caused by excessive hepatic lipid accumulation and peroxidation. Vitamin E has become a standard treatment for NASH. Astaxanthin and metabolic function

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